Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

Sarah L Booth; Jacqueline M Charnley; James A Sadowski; Edward Saltzman; Edwin G Bovill; Mary Cushman

doi:10.1055/s-0038-1655997

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 77(03): 504-509
DOI: 10.1055/s-0038-1655997

Coagulation

Schattauer GmbH Stuttgart

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K₁ Content

Sarah L Booth

¹The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA

,

Jacqueline M Charnley

²The Dept. of Local Health, State of Vermont, USA

,

James A Sadowski

¹The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA

,

Edward Saltzman

¹The Jean Mayer USDA Human Nutrition Center on Aging, Tufts University, Boston, USA

,

Edwin G Bovill

³The Dept. of Local Health, University of Vermont, Burlington, USA

,

Mary Cushman

³The Dept. of Local Health, University of Vermont, Burlington, USA

› Author Affiliations

Abstract

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Summary

Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K₁ dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K₁ content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K₁, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K₁-coumarin interaction. The dietary guidelines reported here may be used in such studies.

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References

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